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Full text release has been delayed at the author's request until May 17, 2025

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Longitudinal Assessment of SARS-CoV-2 Hybrid Immunity Antibody Kinetics in Nursing Home Residents

Paxitzis, Alexandra N
http://rave.ohiolink.edu/etdc/view?acc_num=case1712182145224599

Abstract Details

2024, Master of Sciences, Case Western Reserve University, Medical Physiology.
Adults over 65 are increasingly susceptible to infections due to the phenomena of immunosenescence and inflammaging. As this population grows in number and COVID- 19 becomes assimilated with yearly illnesses, assessment of the longitudinal immune response to infection and vaccination is paramount to recommending a vaccination schedule that maximizes the senescent immune system’s capabilities. As a continuation of a longitudinal study, sera were collected from NHRs in Northeast Ohio at different time points in their vaccination series. Binding and pseudovirus neutralization assays were performed to assess antibody response against SARS-CoV-2, and decay character was compared between infection histories. We hypothesized that infection history modulates decay. Through assays and data analysis, we found that those with prior infection exhibit greater antibody longevity, and that vaccinations should be administered every 6 months to minimize antibody decay.
Andrea Romani (Committee Chair)
Jürgen Bosch (Committee Member)
George Dubyak (Committee Member)
David Canaday (Advisor)
60 p.
Immunology; Physiology
SARS-CoV-2; antibody decay; nursing home residents; antibody kinetics; COVID-19; SARS-CoV-2 antibodies; immunosenescence; longitudinal antibody decay; COVID-19 vaccine; COVID-19 vaccine response; longitudinal COVID-19 vaccine antibody response

Recommended Citations

Citations

  • Paxitzis, A. N. (2024). Longitudinal Assessment of SARS-CoV-2 Hybrid Immunity Antibody Kinetics in Nursing Home Residents [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1712182145224599

    APA Style (7th edition)

  • Paxitzis, Alexandra. Longitudinal Assessment of SARS-CoV-2 Hybrid Immunity Antibody Kinetics in Nursing Home Residents. 2024. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1712182145224599.

    MLA Style (8th edition)

  • Paxitzis, Alexandra. "Longitudinal Assessment of SARS-CoV-2 Hybrid Immunity Antibody Kinetics in Nursing Home Residents." Master's thesis, Case Western Reserve University, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=case1712182145224599

    Chicago Manual of Style (17th edition)

case1712182145224599
© 2024, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.