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Full text release has been delayed at the author's request until May 17, 2025

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HEALTH-RELATED SOCIAL NEEDS AND CANCER BURDEN IN PERSONS LIVING WITH HUMAN IMMUNODEFICIENCY VIRUS

Zhou, Guangjin
http://rave.ohiolink.edu/etdc/view?acc_num=case170611050047593

Abstract Details

2024, Doctor of Philosophy, Case Western Reserve University, Clinical Research.
Objective: To assess the impact of health-related social needs (HRSN) on hospital readmission and cancer prevalence in persons living with HIV (PLWH). Study population and methods: For the HRSN work, I utilized four-year (2016-2019) longitudinal State Inpatient Databases (SID) from Florida and Maryland. The study encompassed 43,229 HIV patients in Florida and 12,396 in Maryland. For the cancer burden work, I used one-year nationwide Medicaid enrollment files. Cancer burden in men and women living with HIV were examined separately. The sample of men included 82,495 with HIV and 7,302,523 without HIV, and that of women included 72,508 with HIV and 17,353,963 without HIV. The traditional statistical and data mining approaches were used to analyze data. Results: Key findings include: (1) A significantly high prevalence of social needs was associated with increased PLWH hospital readmission, and these needs emerged as critical elements in predicting hospital readmission. (2) The spectrum of cancer burden differed by gender, but anal cancer and non- xi Hodgkin’s lymphoma (NHL) were consistently among the most prevalent cancer types in both men and women. (3) Among men living with HIV, the prevalence of non-AIDS defining cancers was about twice that of men without HIV, with anal cancer and non-Hodgkin’s lymphoma having the highest prevalence. (4) Among women living with HIV, cervical cancer, Kaposi’s sarcoma, anal cancer, and Hodgkin’s and non-Hodgkin’s lymphoma remained highly prevalent. (5) Age had a more robust modification effect in younger HIV patients compared to the non-HIV population of same age range. Implications: This study both identified the pivotal role of health-related social needs in hospital readmission and elucidated cancer disparities in PLWH. It is imperative for healthcare providers and policymakers to acknowledge social factors as critical in reducing hospital readmissions for HIV patients. Recognizing cancer disparities is essential for developing targeted interventions and improving healthcare outcomes for both men and women living with HIV. Initiating HPV vaccination for anal and cervical cancer should target adolescents and young adults among HIV patients. Additionally, cancer prevention and screening should prioritize high-risk minority PLWH from an early age.
Siran Koroukian (Advisor)
Nicholas Schiltz (Committee Member)
Laura v Mintz (Committee Member)
James S Spilsbury (Committee Chair)
Epidemiology

Recommended Citations

Citations

  • Zhou, G. (2024). HEALTH-RELATED SOCIAL NEEDS AND CANCER BURDEN IN PERSONS LIVING WITH HUMAN IMMUNODEFICIENCY VIRUS [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case170611050047593

    APA Style (7th edition)

  • Zhou, Guangjin. HEALTH-RELATED SOCIAL NEEDS AND CANCER BURDEN IN PERSONS LIVING WITH HUMAN IMMUNODEFICIENCY VIRUS . 2024. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case170611050047593.

    MLA Style (8th edition)

  • Zhou, Guangjin. "HEALTH-RELATED SOCIAL NEEDS AND CANCER BURDEN IN PERSONS LIVING WITH HUMAN IMMUNODEFICIENCY VIRUS ." Doctoral dissertation, Case Western Reserve University, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=case170611050047593

    Chicago Manual of Style (17th edition)

case170611050047593
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This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.
Release 3.2.12