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CRSPThesis_LindsayRoss_Final.pdf (2.4 MB)

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Associations of Hypothalamic Subregional Volumes with Fatigue, Sleep Disturbance, and Depression in a Large Cohort of Patients with Multiple Sclerosis

Ross, Lindsay
http://orcid.org/0000-0002-7323-1219
http://rave.ohiolink.edu/etdc/view?acc_num=case1654796865320597

Abstract Details

2022, Master of Sciences, Case Western Reserve University, Clinical Research.
Background: Evaluating associations between fatigue, sleep disturbance, and depression and hypothalamic subregional volumes (HSVs) in multiple sclerosis (MS) may further the understanding of the pathophysiological substrates of these disabling symptoms. Methods: MS patients from two centers seen between September 10, 2015 and June 30, 2020 who completed an MRI of the brain within seven days of a visit were included. Automated segmentation of T1-weighted MRIs was performed to obtain 10 HSVs. Relationships between fatigue, sleep disturbance, and depression and HSVs were evaluated by linear models. Results: 1962 patients were included. Among the HSVs, the right anterior inferior subregion had the largest standardized correlation coefficient (Beta) for fatigue (Beta= -0.049, 95% CI [-0.090, -0.009]) and sleep disturbance (Beta= 0.047, 95% CI [0.008, 0.085]). There was no statistically detectable relationship between depression and any HSV. Conclusion: These findings support a role of the anterior inferior subregion, including the suprachiasmatic nucleus, fatigue and sleep disturbance in MS.
Kedar Mahajan (Committee Chair)
Gustavo Heresi Davila (Committee Member)
Daniel Ontaneda (Committee Member)
Jeffrey Cohen (Committee Member)
122 p.
Medicine; Mental Health; Neurology
Multiple Sclerosis; Hypothalamus; Fatigue; Sleep Disturbance; Depression; Hypothalamic Subregion; MRI

Recommended Citations

Citations

  • Ross, L. (2022). Associations of Hypothalamic Subregional Volumes with Fatigue, Sleep Disturbance, and Depression in a Large Cohort of Patients with Multiple Sclerosis [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1654796865320597

    APA Style (7th edition)

  • Ross, Lindsay. Associations of Hypothalamic Subregional Volumes with Fatigue, Sleep Disturbance, and Depression in a Large Cohort of Patients with Multiple Sclerosis. 2022. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1654796865320597.

    MLA Style (8th edition)

  • Ross, Lindsay. "Associations of Hypothalamic Subregional Volumes with Fatigue, Sleep Disturbance, and Depression in a Large Cohort of Patients with Multiple Sclerosis." Master's thesis, Case Western Reserve University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=case1654796865320597

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.