Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


ascha-dissertation.pdf (4.39 MB)

ETD Abstract Container

Abstract Header

Incidence and Treatment of Brain Metastases Arising from Lung, Breast, or Skin Cancers: Real-World Evidence from Primary Cancer Registries and Medicare Claims

Ascha, Mustafa Steven
http://orcid.org/0000-0003-4706-7379
http://rave.ohiolink.edu/etdc/view?acc_num=case1554481284740082

Abstract Details

2019, Doctor of Philosophy, Case Western Reserve University, Clinical Research.
Brain metastases (BM) are the most frequent type of brain tumor, and cause significant morbidity and mortality. As imaging modalities improve, treatments improve and diagnoses increase in frequency, epidemiological studies of BM and its clinical outcomes become increasingly relevant and potentially beneficial to cancer patients. Here, we use large population-level data from the Surveillance, Epidemiology, and End-Results (SEER) program combined with Medicare claims to identify measures of BM incidence, claims algorithm concordance with SEER data, treatment patterns, and treatment efficacy for patients with BM arising from primary lung, breast, or skin cancers. We make use of both traditional epidemiological approaches to minimize confounding, such as age adjustment to a standard population, and more advanced methods, such as propensity score matching. By examining the Medicare claims of patients diagnosed with BM, the following chapters shed light on which patients develop BM, how BM patients benefit from an antineoplastic drug that may simultaneously relieve intracranial hypertension, and which patient populations are underserved with respect to BM treatment.
Jill Barnholtz-Sloan, PhD (Advisor)
Fredrick Schumacher, PhD (Committee Chair)
Jeremy Bordeaux, MD (Committee Member)
Andrew Sloan, MD (Committee Member)
182 p.
Biostatistics; Epidemiology; Health Sciences; Medicine; Neurology; Oncology
brain metastases; cancer; oncology; real-world evidence; Surveillance, Epidemiology, and End-Results; SEER; Medicare claims; reproducibility; epidemiology; biostatistics; lung cancer; breast cancer; melanoma

Recommended Citations

Citations

  • Ascha, M. S. (2019). Incidence and Treatment of Brain Metastases Arising from Lung, Breast, or Skin Cancers: Real-World Evidence from Primary Cancer Registries and Medicare Claims [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1554481284740082

    APA Style (7th edition)

  • Ascha, Mustafa. Incidence and Treatment of Brain Metastases Arising from Lung, Breast, or Skin Cancers: Real-World Evidence from Primary Cancer Registries and Medicare Claims. 2019. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1554481284740082.

    MLA Style (8th edition)

  • Ascha, Mustafa. "Incidence and Treatment of Brain Metastases Arising from Lung, Breast, or Skin Cancers: Real-World Evidence from Primary Cancer Registries and Medicare Claims." Doctoral dissertation, Case Western Reserve University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1554481284740082

    Chicago Manual of Style (17th edition)

case1554481284740082
153
© 2019, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.