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Thesis JeShaune Jackson 3_18.pdf (8.35 MB)

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Bench to Bone: Commercializing a Cellular Therapeutic for Regenerative Medicine

Jackson, JeShaune D, Jackson
http://orcid.org/0000-0001-7744-5428
http://rave.ohiolink.edu/etdc/view?acc_num=case1521472107740449

Abstract Details

2018, Master of Sciences, Case Western Reserve University, Biology.
All bone regeneration requires bone forming cells (osteogenic connective tissue progenitors, CTP-Os). This thesis examines a clinically practiced method for selecting and rapidly concentrating CTP-Os for transplantation at point-of-care. Annually in the US alone, more than 1.5M bone regeneration procedures are performed. Autografting is the most common and often involves harvesting bone and bone marrow from the patient’s hip and transferring to the site where new bone formation is desired. Autografting is preferred because it provides a graft material that contains viable ostoegenic cells (CTP-Os) that are immune compatible, has correct bone formation inducing proteins, and provides structural scaffold for bone ingrowth. However, due to pain, bleeding and scarring from the additional surgery, less invasive solutions have been demanded. Selective retention provides the properties needed for bone growth without the need for an additional procedure. This thesis describes the life cycle of a product from the lab to the market.
George Muschler, MD (Committee Chair)
Christopher Cullis, PhD (Committee Member)
Elizabeth Sump, MS (Committee Member)
Stephen Haynesworth, PhD (Committee Member)
147 p.
Biology; Biomedical Engineering; Entrepreneurship
Stem cells, business, entrepreneurship, venture capital, bone, regenerative medicine, biologics, tissue engineering, biotechnology

Recommended Citations

Citations

  • Jackson, Jackson, J. D. (2018). Bench to Bone: Commercializing a Cellular Therapeutic for Regenerative Medicine [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1521472107740449

    APA Style (7th edition)

  • Jackson, Jackson, JeShaune. Bench to Bone: Commercializing a Cellular Therapeutic for Regenerative Medicine. 2018. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1521472107740449.

    MLA Style (8th edition)

  • Jackson, Jackson, JeShaune. "Bench to Bone: Commercializing a Cellular Therapeutic for Regenerative Medicine." Master's thesis, Case Western Reserve University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1521472107740449

    Chicago Manual of Style (17th edition)

case1521472107740449
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© 2018, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.