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Immuno-nanotherapeutics to Inhibit Macrophage Polarization for Non-Small-Cell Lung Cancers

Seshadri, Dhruv Ramakrishna
http://rave.ohiolink.edu/etdc/view?acc_num=case151084330337552

Abstract Details

2017, Master of Sciences, Case Western Reserve University, Biomedical Engineering.
Lung cancer is the leading cause of cancer-related mortalities in the USA with a five-year survival rate of ~15%. For patients with Non-Small-Cell Lung Cancer (NSCLC), chemotherapy, oncogene targeted therapy, or immunotherapy are the primary modes of treatment. Response rates to immunotherapies for NSCLCs are < 20%, due to the tumor micro-environment (TME) that favors immune-evasion and pro-tumorigenic pathways such as macrophage polarization from a pro-inflammatory (M1) to a pro-tumorigenic/angiogenic (M2) phenotype. Additionally, the TME is compromised by the chronic enzymatic breakdown of the elastic matrix which catalyzes polarization. Exogenous delivery of Doxycycline (DOX) has shown to inhibit the M1-M2 phenotypic switch. We explored the utility of antibody-conjugated DOX-poly(ethylene glycol)-poly(lactic glycolic-acid) (PEG-PLGA) nanoparticles (NPs) to inhibit macrophage polarization and demonstrate that steady-state release of DOX from these NPs is possible in a low dose range to inhibit polarization and repolarize macrophages back to the M1 phenotype.
Anand Ramamurthi (Advisor)
Eben Alsberg (Committee Member)
Colin Drummond (Committee Member)
135 p.
Biomedical Engineering; Biomedical Research; Polymer Chemistry; Polymers
Tumor Microenvironment, Nanomedicine, Nanoparticles, Polymers, Lung Cancer, Macrophages, Immunotherapy, Extracellular Matrix, Elastin

Recommended Citations

Citations

  • Seshadri, D. R. (2017). Immuno-nanotherapeutics to Inhibit Macrophage Polarization for Non-Small-Cell Lung Cancers [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case151084330337552

    APA Style (7th edition)

  • Seshadri, Dhruv. Immuno-nanotherapeutics to Inhibit Macrophage Polarization for Non-Small-Cell Lung Cancers. 2017. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case151084330337552.

    MLA Style (8th edition)

  • Seshadri, Dhruv. "Immuno-nanotherapeutics to Inhibit Macrophage Polarization for Non-Small-Cell Lung Cancers." Master's thesis, Case Western Reserve University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case151084330337552

    Chicago Manual of Style (17th edition)

case151084330337552
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© 2017, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.