Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


Dissertation-JiangJingle-final_v3.pdf (9.31 MB)

ETD Abstract Container

Abstract Header

ASSESSMENT OF FACTORS RELATED TO CHRONIC INTRACORTICAL RECORDING RELIABILITY

Jingle, Jiang
http://orcid.org/0000-0003-1467-173X
http://rave.ohiolink.edu/etdc/view?acc_num=case1480417757397073

Abstract Details

2017, Doctor of Philosophy, Case Western Reserve University, Biomedical Engineering.
Intracoritcal microelectrodes recording technology has significantly contributed to scientific researches on Central Nervous System (CNS), and also enabled exciting new applications like Brain-Machine-Interface. The attractiveness of the technology lies on their ability to record single neuron’s firing events, i.e. action potentials. Together with advanced signal processing algorithms, researchers could accurately detect when an action potential occurs, as well as attribute each action potential to its appropriate neurons. However, engineering application of intracortical microelectrode recording technology is currently hindered by the inability to reliably record chronic neuronal signals. The precise mechanism of long term recording failure is still not clear, but CNS immune response toward implanted foreign body has been commonly hypothesized as a main cause. Currently, the “gold standard” method for assessing CNS immune response is immunohisotochemistry (IHC), which is a lethal method where the implanted electrode needs to be explanted and host animal needs to be sacrificed. This results in several limitations of this method, including but not limited to, the inability to perform predictive experiment (i.e. assess the degree of CNS immune response before experiment ends) rather than purely explanatory experiment (i.e. assess the degree of CNS immune response after experiment ends). This dissertation has two independent goals. First, an alternative non-lethal method to assess CNS immune response was investigated. Electrical Impedance Spectroscopy (EIS) has been preliminarily reported as sensitive to the degree of CNS immune response surrounding the measured electrode. Unfortunately, the very limited number of reports on this phenomenon has been incomplete and knowledge of microelectrode’s chronic EIS characteristics is missing. In addition, no attempt has been made to use EIS’s potential of reflecting CNS immune response to correlate with electrode recording performance. If successful, the work proposed here will unveil a powerful non-lethal research tool in future CNS immunology researches and ultimately benefits the research on electrode failure mechanisms. Second, we developed and assessed an advanced signal processing method which enabled extraction of more information from microelectrode recordings than we currently could. A better signal processing method can obtain more useful information even if recording quality inevitably declined (regardless of its causes). These two studies together seek to increase the functioning window of implanted intracortical microelectrodes, with the hope of ultimately enabling practical and chronic applications of the intracortical microelectrode recording technology.
Dawn Taylor (Advisor)
Jeffrey Capadona (Committee Chair)
270 p.
Engineering
Intracortical recording, brain computer interface, impedance, common spatial filter, denoising, pattern recognition

Recommended Citations

Citations

  • Jingle, J. (2017). ASSESSMENT OF FACTORS RELATED TO CHRONIC INTRACORTICAL RECORDING RELIABILITY [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1480417757397073

    APA Style (7th edition)

  • Jingle, Jiang. ASSESSMENT OF FACTORS RELATED TO CHRONIC INTRACORTICAL RECORDING RELIABILITY . 2017. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1480417757397073.

    MLA Style (8th edition)

  • Jingle, Jiang. "ASSESSMENT OF FACTORS RELATED TO CHRONIC INTRACORTICAL RECORDING RELIABILITY ." Doctoral dissertation, Case Western Reserve University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1480417757397073

    Chicago Manual of Style (17th edition)

case1480417757397073
260
© 2016, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.
Release 3.2.12