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METABOLIC SYNDROME IN AN IMMUNOSUPPRESSED POPULATION: GENETIC CONTRIBUTION TO METABOLIC SYNDROME TRAITS IN THE WOMEN'S INTERAGENCY HIV STUDY

Natanzon, Yanina
http://rave.ohiolink.edu/etdc/view?acc_num=case1449252475

Abstract Details

2016, Doctor of Philosophy, Case Western Reserve University, Epidemiology and Biostatistics.
This is a study to evaluate cross-sectional and longitudinal genetic associations among Metabolic Syndrome (MetS) risk factors and a select set of candidate genes involved in inflammatory, vasoconstrictive, and coagulation processes at the vascular epithelium in the Women's Interagency HIV Study (WIHS) Cohort. We conducted a candidate gene association analysis of multiple clinical measures for each component trait of MetS in a group of HIV-positive and -negative women of the WIHS. Thirty-two candidate genes were selected based on their pro-inflammatory, pro-vasoconstrictive, and pro-coagulative functions and expression in the vascular endothelium. The association was modeled with mixed effects model with both random slope and random intercepts. We have identified genetic variants in CKD14 and NFKB1 with longitudinal effects on MetS risk factors in African Americans and Hispanics. We provide evidence that the genetic architecture of MetS includes genes previously implicated in inflammation (NFKB1) and vessel repair (CDK14) and that HIV may mediate the magnitude of the some genetic associations.
Xiaofeng Zhu, Ph.D. (Committee Chair)
Robert Elston, Ph.D. (Committee Member)
Nathan Morris, Ph.D. (Committee Member)
Nora Nock, Ph.D. (Committee Member)
Barbara Gripshover, M.D. (Committee Member)
Bradely Aoiuzerat, Ph.D. (Committee Member)
120 p.
Epidemiology; Genetics
Metabolic Syndrome; HIV; Womens Interagency HIV Study; WIHS; Inflammation; Longitudinal genetic analysis; Pulse pressure; NFKB1; CDK14; Cardiovascular Disease; Repeated measures analysis; Genetics; Genetic Epidemiology; Hispanics; African Americans;

Recommended Citations

Citations

  • Natanzon, Y. (2016). METABOLIC SYNDROME IN AN IMMUNOSUPPRESSED POPULATION: GENETIC CONTRIBUTION TO METABOLIC SYNDROME TRAITS IN THE WOMEN'S INTERAGENCY HIV STUDY [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1449252475

    APA Style (7th edition)

  • Natanzon, Yanina. METABOLIC SYNDROME IN AN IMMUNOSUPPRESSED POPULATION: GENETIC CONTRIBUTION TO METABOLIC SYNDROME TRAITS IN THE WOMEN'S INTERAGENCY HIV STUDY. 2016. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1449252475.

    MLA Style (8th edition)

  • Natanzon, Yanina. "METABOLIC SYNDROME IN AN IMMUNOSUPPRESSED POPULATION: GENETIC CONTRIBUTION TO METABOLIC SYNDROME TRAITS IN THE WOMEN'S INTERAGENCY HIV STUDY." Doctoral dissertation, Case Western Reserve University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1449252475

    Chicago Manual of Style (17th edition)

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© 2016, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.