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Treprostinil thesis12.pdf (589.88 KB)

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Treprostinil Iontophoresis In Idiopathic Pulmonary Arterial Hypertension

Tonelli, Adriano R
http://orcid.org/0000-0002-2321-9545
http://rave.ohiolink.edu/etdc/view?acc_num=case1427825349

Abstract Details

2015, Master of Sciences, Case Western Reserve University, Clinical Research.
Objective: Abnormalities in the prostacyclin pathway are involved in pathobiology of pulmonary arterial hypertension (PAH) and can be studied noninvasively by cutaneous treprostinil iontophoresis. Methods: Treprostinil iontophoresis was tested in 24 patients with idiopathic or heritable PAH and 25 age- and gender-matched controls, between 2/2013 and 2/2015. Results: The percentage change in perfusion units (PUs) with treprostinil iontophoresis was significantly reduced in IPAH patients compared with matched controls (median (interquartile range) 246 (96-605) versus 538 (381-1,035), p=0.004). The peak PUs were associated with NYHA functional class (R=-0.35, p=0.01), number of PAH therapies (R=0.48, p=0.02) and cardiac index (R=0.41, p=0.05, respectively). Lower peak PUs related to increased oxidative stress and arginine methylation products in plasma. Conclusion: Patients with IPAH have a decrease in the cutaneous microvascular response to treprostinil iontophoresis compared with matched controls; a finding that can be due to increased oxidative stress and abnormalities of the nitric oxide pathway.
Raed Dweik, MD (Committee Chair)
Wilson Tang, MD (Committee Member)
James Spilsbury, PhD (Committee Member)
41 p.
Health Sciences; Medicine
Pulmonary arterial hypertension; treprostinil; iontophoresis; microvascular dysfunction

Recommended Citations

Citations

  • Tonelli, A. R. (2015). Treprostinil Iontophoresis In Idiopathic Pulmonary Arterial Hypertension [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1427825349

    APA Style (7th edition)

  • Tonelli, Adriano. Treprostinil Iontophoresis In Idiopathic Pulmonary Arterial Hypertension. 2015. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1427825349.

    MLA Style (8th edition)

  • Tonelli, Adriano. "Treprostinil Iontophoresis In Idiopathic Pulmonary Arterial Hypertension." Master's thesis, Case Western Reserve University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1427825349

    Chicago Manual of Style (17th edition)

case1427825349
738
© 2015, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.