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Thesis_ETD_KLWright_Oct2014_v3.pdf (6.05 MB)

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Measuring Perfusion with Magnetic Resonance Imaging using Novel Data Acquisition and Reconstruction Strategies

Wright, Katherine L
http://rave.ohiolink.edu/etdc/view?acc_num=case1412786849

Abstract Details

2015, Doctor of Philosophy, Case Western Reserve University, Biomedical Engineering.
Tissue perfusion is an important metric that can provide valuable information for disease diagnosis, treatment planning, and treatment follow-up. MRI can quantify perfusion both with and without Gd-based contrast agents, and can provide spatially-localized perfusion maps. However, these techniques are rarely used in the clinical environment. The works in this thesis focused on providing novel data acquisition and/or reconstruction techniques to overcome limitations in DCE MRI and ASL in order to provide clinically-viable perfusion exams. There are three main projects that will be described in this thesis. First, a simultaneous 3D magnetic resonance angiography and perfusion (MRAP) exam is proposed and is demonstrated in the distal lower extremities. Second, a 3D non-Cartesian parallel imaging method is described and used to achieve a low-dose, 3D, high spatiotemporal resolution renal DCE MRI exam that is acquired without breath-holding. Finally, a novel approach to ASL is proposed using the Magnetic Resonance Fingerprinting framework to simultaneously quantify perfusion, transit time, and tissue T1 in a single, efficient acquisition.
Vikas Gulani, M.D., Ph.D. (Advisor)
David Wilson, Ph.D. (Committee Chair)
Mark Griswold, Ph.D. (Committee Member)
Anant Madabhushi, Ph.D. (Committee Member)
Michael Martens, Ph.D. (Committee Member)
187 p.
Biomedical Engineering
Magnetic Resonance Imaging; Perfusion; Dynamic Contrast Enhanced MRI; Arterial Spin Labeling

Recommended Citations

Citations

  • Wright, K. L. (2015). Measuring Perfusion with Magnetic Resonance Imaging using Novel Data Acquisition and Reconstruction Strategies [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1412786849

    APA Style (7th edition)

  • Wright, Katherine. Measuring Perfusion with Magnetic Resonance Imaging using Novel Data Acquisition and Reconstruction Strategies. 2015. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1412786849.

    MLA Style (8th edition)

  • Wright, Katherine. "Measuring Perfusion with Magnetic Resonance Imaging using Novel Data Acquisition and Reconstruction Strategies." Doctoral dissertation, Case Western Reserve University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1412786849

    Chicago Manual of Style (17th edition)

case1412786849
684
© 2014, some rights reserved.Creative Commons License Measuring Perfusion with Magnetic Resonance Imaging using Novel Data Acquisition and Reconstruction Strategies by Katherine L Wright is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.