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Effects of Exercise Therapy on Functional Connectivity in Parkinson's Disease

Shah, Chintan
http://rave.ohiolink.edu/etdc/view?acc_num=case1364514398

Abstract Details

2013, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
Forced-rate lower-extremity exercise has recently emerged as a potential safe and low-cost therapy for Parkinson's Disease (PD). The efficacy is believed to be dependent on high rates of exercise. In this study, we use functional connectivity (FC) MRI to further elucidate the mechanism underlying this rate-dependent effect. PD subjects were randomized to complete 8 weeks of forced, voluntary, or no exercise. Changes in brain connectivity were then analyzed as a function of pedaling rate. Changes in task-related FC (trFC) from the most affected motor cortex (*M1) to the ipsilateral thalamus were significantly positively correlated to pedaling rate. Changes in trFC between *M1 and the supplementary motor area were significantly negatively correlated to pedaling rate. This relationship persisted after 4 weeks of follow up. This indicates that patients who pedal faster tend to show stronger increases in cortico-subcortical trFC, and stronger decreases in cortico-cortical trFC.
Jay Alberts, Ph.D. (Advisor)
Kenneth Gustafson, Ph.D. (Committee Chair)
Micheal Phillips, M.D. (Committee Member)
Hubert Fernandez, M.D. (Committee Member)
Mark Lowe, Ph.D. (Other)
Erik Beall, Ph.D. (Other)
51 p.
Biomedical Engineering; Medical Imaging; Neurosciences
Parkinson's Disease; exercise; Functional Connectivity; fMRI; fcMRI

Recommended Citations

Citations

  • Shah, C. (2013). Effects of Exercise Therapy on Functional Connectivity in Parkinson's Disease [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1364514398

    APA Style (7th edition)

  • Shah, Chintan. Effects of Exercise Therapy on Functional Connectivity in Parkinson's Disease. 2013. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1364514398.

    MLA Style (8th edition)

  • Shah, Chintan. "Effects of Exercise Therapy on Functional Connectivity in Parkinson's Disease." Master's thesis, Case Western Reserve University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1364514398

    Chicago Manual of Style (17th edition)

case1364514398
469
© 2013, some rights reserved.Creative Commons License Effects of Exercise Therapy on Functional Connectivity in Parkinson's Disease by Chintan Shah is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.