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The Role of the Leptin Receptor on T Cells in Helicobacter Pylori Infection and Clearance in Mice

Emancipator, Douglas Steven
http://rave.ohiolink.edu/etdc/view?acc_num=case1216744504

Abstract Details

2008, Master of Sciences, Case Western Reserve University, Biology.
Helicobacter pylori (H. pylori) infects the stomach of over half of the worlds population and often results in gastritis and ulcers. In addition, the World Health Organization has categorized H. pylori as a class I carcinogen. Still, little is known about how H. pylori induced gastritis arises and resolves. The adaptive immune response to H. pylori shapes proclivity to gastritis and clearance of infection. Recently, interaction of Leptin with its receptor has been recognized to modulate immune responses, and particularly reduces the T cells ability to incite inflammation. We hypothesized that the LepR modulates the adaptive immune response and thereby plays a significant role in the clearance of H. pylori from gastric mucosa. The data indicate that the LepR on CD4+ T cells is required for clearance of H. pylori from infected SCID mice adoptively transferred with T cells.
James Zull, PhD (Committee Chair)
Nancy DiIulio, PhD (Advisor)
John Nedrud, PhD (Committee Member)
Radhika Atit, PhD (Committee Member)
28 p.
Biology; Biomedical Research; Immunology
Helicobacter pylori; Leptin receptor; adaptive immune response

Recommended Citations

Citations

  • Emancipator, D. S. (2008). The Role of the Leptin Receptor on T Cells in Helicobacter Pylori Infection and Clearance in Mice [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1216744504

    APA Style (7th edition)

  • Emancipator, Douglas. The Role of the Leptin Receptor on T Cells in Helicobacter Pylori Infection and Clearance in Mice. 2008. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1216744504.

    MLA Style (8th edition)

  • Emancipator, Douglas. "The Role of the Leptin Receptor on T Cells in Helicobacter Pylori Infection and Clearance in Mice." Master's thesis, Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1216744504

    Chicago Manual of Style (17th edition)

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© 2008, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.