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GENE BY ENVIRONMENT INTERACTION IN LINKAGE ANALYSIS: THE EFFECTS OF BODY MASS INDEX ON SYSTEMIC LUPUS ERYTHEMATOSUS

Goodloe, Robert James, Jr
http://rave.ohiolink.edu/etdc/view?acc_num=case1207337790

Abstract Details

2008, Master of Sciences, Case Western Reserve University, Epidemiology and Biostatistics.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease known to have both environmental and genetic causes. The presences of these multiple factors can make the identification of genes for complex diseases, like lupus, complicated. The inclusion of environmental factors into the genetic models can play an important role in the localization of disease genes. We conducted a genome-wide linkage scan for SLE, body mass index (BMI), and SLE using BMI as a covariate, including European American and African American population subsets. The analysis used three approaches: Haseman-Elston Variance-Component-based (SIBPAL, S.A.G.E.[v5.4]), One parameter Conditional Logistic Regression-based (LODPAL, S.A.G.E.[v5.4]) and Ordered Subset Analysis Stratum-based (OSA, OSA[v2.1]) method. We found suggestive evidence for candidate regions on chromosomes 3q29, 6q26-27, and 13p11.3-q11 in the European American population and on chromosome 20p13-12 in the African American population. These results support a potential role of obesity in the etiology of lupus.
Courtney Gray-McGuire, PhD (Advisor)
Courtney Gray-McGuire, PhD (Committee Chair)
Robert Elston, PhD (Committee Member)
Catherine Stein, PhD (Committee Member)
74 p.
Epidemiology
gene by environment interaction; lupus; BMI; linkage analysis

Recommended Citations

Citations

  • Goodloe, Jr, R. J. (2008). GENE BY ENVIRONMENT INTERACTION IN LINKAGE ANALYSIS: THE EFFECTS OF BODY MASS INDEX ON SYSTEMIC LUPUS ERYTHEMATOSUS [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1207337790

    APA Style (7th edition)

  • Goodloe, Jr, Robert. GENE BY ENVIRONMENT INTERACTION IN LINKAGE ANALYSIS: THE EFFECTS OF BODY MASS INDEX ON SYSTEMIC LUPUS ERYTHEMATOSUS. 2008. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1207337790.

    MLA Style (8th edition)

  • Goodloe, Jr, Robert. "GENE BY ENVIRONMENT INTERACTION IN LINKAGE ANALYSIS: THE EFFECTS OF BODY MASS INDEX ON SYSTEMIC LUPUS ERYTHEMATOSUS." Master's thesis, Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1207337790

    Chicago Manual of Style (17th edition)

case1207337790
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© 2008, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.