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case1196287582.pdf (265.23 KB)
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Abstract Header
OASIS AND XBP-1 ACTIVITY IN OSTEOBLAST DIFFERENTIATION AND OSTEOSARCOMA
Author Info
Brister, Aaron B.
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=case1196287582
Abstract Details
Year and Degree
2008, Master of Sciences, Case Western Reserve University, Physiology and Biophysics.
Abstract
The Unfolded Protein Response (UPR) within the Endoplasmic Reticulum (ER) is a quality control mechanism ensuring properly folded proteins. OASIS and XBP-1 are two signal carriers of the UPR. The UPR is linked to tissue and cancer development. Elevated OASIS and XBP-1 activity are observed within developing osteoblasts. Additionally, heightened OASIS activity is present within osteosarcoma while sustained XBP-1 activity, unreported in osteosarcoma, is observed in other cancers. These signaling proteins may mediate development of mature osteoblasts and osteosarcomas. Therefore, evidence is presented with supporting mechanistic hypotheses indicating unique functions for OASIS and XBP-1 in osteoblast differentiation and osteosarcoma. These functions include, but are not limited to, enlarging the ER, buffering unfolded protein accumulation, mitigating UPR-induced cell death, and processing soluble ER proteins destined for secretion.
Committee
Edward Greenfield (Advisor)
Keywords
XBP-1
;
GRP78
;
OASIS
;
OSTEOBLAST
;
OASIS AND XBP-1
;
Protein
;
UPR
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Citations
Brister, A. B. (2008).
OASIS AND XBP-1 ACTIVITY IN OSTEOBLAST DIFFERENTIATION AND OSTEOSARCOMA
[Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1196287582
APA Style (7th edition)
Brister, Aaron.
OASIS AND XBP-1 ACTIVITY IN OSTEOBLAST DIFFERENTIATION AND OSTEOSARCOMA.
2008. Case Western Reserve University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=case1196287582.
MLA Style (8th edition)
Brister, Aaron. "OASIS AND XBP-1 ACTIVITY IN OSTEOBLAST DIFFERENTIATION AND OSTEOSARCOMA." Master's thesis, Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1196287582
Chicago Manual of Style (17th edition)
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Document number:
case1196287582
Download Count:
1,155
Copyright Info
© 2007, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.