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Xinhao Liu_dissertation_edited.pdf (4.09 MB)

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Structural Insight into Self-assembly of Coacervate-forming Polyesteramides

Liu, Xinhao
http://orcid.org/0000-0002-5640-1837
http://rave.ohiolink.edu/etdc/view?acc_num=akron1658661513154633

Abstract Details

2022, Doctor of Philosophy, University of Akron, Polymer Science.
Cells are highly ordered, structurally complex systems with billions of years of evolution. There are great endeavors in understanding how biological components and biomolecular processes shape the diverse living systems today. Recent progress in cellular biology pointed out the key role of coacervates in numerous extracellular and intracellular activities, including stress response, gene regulation, signaling, extracellular load-bearing matrix, and underwater adhesion. Inspired by nature, material scientists utilize synthetic coacervates for various applications, including underwater adhesives and therapeutic protein delivery. Growing evidence has verified biological coacervates are driven by collective interactions, which offer coacervates remarkable robustness in highly diverse living systems. Currently, coacervate-forming synthetic materials are mainly induced by electrostatic interaction, which shows instability in complex environmental conditions. Here, a new library of coacervate-forming polyesteramides driven by hydrophobic interactions and stabilized by bridged hydrogen bonding is presented. The polyesteramides are prepared by ring-opening polymerization, which provides controllability in molecular structure, end group functionality, and molecular weight. These polyesteramide coacervates demonstrate low viscosity, low interfacial energy, and the capability to form multilayered structures analog to biological coacervates. The phase behavior and physical properties can be controlled by varying chemical structures and the temperature. This study provides a stepping stone to developing biomimetic synthetic coacervates for understanding cellular activities and designing advanced coacervate-based materials.
Abraham Joy (Advisor)
Mesfin Tsige (Committee Member)
Chunming Liu (Committee Member)
Ali Dhinojwala (Committee Member)
Adam Smith (Committee Member)
128 p.
Polymers
Simple coacervates, hydrogen bonding, hydrophobic interaction, viscosity, interfacial energy, multiphasic coacervation, polyesteramides, degradable, controlled ring opening polymerization

Recommended Citations

Citations

  • Liu, X. (2022). Structural Insight into Self-assembly of Coacervate-forming Polyesteramides [Doctoral dissertation, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1658661513154633

    APA Style (7th edition)

  • Liu, Xinhao. Structural Insight into Self-assembly of Coacervate-forming Polyesteramides. 2022. University of Akron, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1658661513154633.

    MLA Style (8th edition)

  • Liu, Xinhao. "Structural Insight into Self-assembly of Coacervate-forming Polyesteramides." Doctoral dissertation, University of Akron, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=akron1658661513154633

    Chicago Manual of Style (17th edition)

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© 2022, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.