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The Effects of Phenylephrine, Sodium Nitroprusside, and Hypoxia on the Heart and Blood Vessels in Danio rerio

Turner, Dakota
http://rave.ohiolink.edu/etdc/view?acc_num=akron1473699326227566

Abstract Details

2016, Master of Science, University of Akron, Biology.
Pharmaceutical medications in waterways are a growing problem worldwide. These include antibiotics, heart medications, and artificial steroids. We examined how a pair of commonly prescribed pharmaceuticals, phenylephrine and sodium nitroprusside, affected the heart and blood vessels in developing zebrafish, Danio rerio. The animals were exposed from 1 day post fertilization (dpf) to 6 dpf. Half of each treatment group was exposed to acute hypoxia on 8 dpf and 15 dpf. On 7 dpf, 8 dpf, 14 dpf, and 15 dpf, heart rate, end diastolic volume, end systolic volume, stroke volume, cardiac output, arterial diameter, and venous diameter were examined via inverted microscope. My results support the concern that pharmaceutical agents can cause physiological changes in locally exposed flora and fauna. Phenylephrine decreased heart rate and vasoconstriction in the veins and hypoxia caused a decrease in heart rate and vasodilation in the arteries.
Brian Bagatto, Ph.D. (Advisor)
Richard Londraville, Ph.D. (Committee Member)
Rolando Ramirez, Ph.D. (Committee Member)
Biology; Environmental Science
danio rerio; phenylephrine; hypoxia; sodium nitroprusside; heart rate; vein diameter; arterial diameter; end systolic volume; end diastolic volume; stroke volume; Cardiac Output;

Recommended Citations

Citations

  • Turner, D. (2016). The Effects of Phenylephrine, Sodium Nitroprusside, and Hypoxia on the Heart and Blood Vessels in Danio rerio [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1473699326227566

    APA Style (7th edition)

  • Turner, Dakota. The Effects of Phenylephrine, Sodium Nitroprusside, and Hypoxia on the Heart and Blood Vessels in Danio rerio. 2016. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1473699326227566.

    MLA Style (8th edition)

  • Turner, Dakota. "The Effects of Phenylephrine, Sodium Nitroprusside, and Hypoxia on the Heart and Blood Vessels in Danio rerio." Master's thesis, University of Akron, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1473699326227566

    Chicago Manual of Style (17th edition)

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This open access ETD is published by University of Akron and OhioLINK.