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The Effects of Acute and Chronic Methamphetamine Exposure on Cardiovascular Development, Developmental Rate, and Aggression in Danio rerio

Ickes, Jessica R
http://rave.ohiolink.edu/etdc/view?acc_num=akron1438456614

Abstract Details

2015, Master of Science, University of Akron, Biology.
The stimulant effects of methamphetamine are known to affect cardiovascular function and behavior in rats and adult humans, but little is known about cardiovascular development in the presence of methamphetamine. The purpose of this study was to determine if methamphetamine exposure (acute and chronic) affects the survivability and cardiovascular development of zebrafish (Danio rerio) embryos. Zebrafish embryos were either injected with a single dose of methamphetamine (acute exposure) or soaked in a methamphetamine solution for 24 hours (chronic exposure). Survival, morphological development, and cardiovascular development were recorded at 48 hours post-fertilization. Embryonic methamphetamine exposure resulted in increased eye size, cardiac output, and red blood cell velocity and a decreased yolk size. Behavior was also assessed in juvenile zebrafish to determine methamphetamine’s role in aggression and avoidance behaviors. Four month old zebrafish were injected with either methamphetamine or a saline control and subjected to mirror image stimulation to quantify aggression. No differences were found in the amount of aggression or avoidance between methamphetamine-exposed fish and control fish. Methamphetamine exposure during development causes select cardiovascular and morphological alterations, while exposure to juvenile fish has no effect on certain behaviors such as aggression and avoidance.
Brian Bagatto, Dr. (Advisor)
Qin Liu, Dr. (Committee Member)
Jordan Renna, Dr. (Committee Member)
70 p.
Biology; Developmental Biology; Physiology
methamphetamine; cardiovascular; cardiac; development; zebrafish; aggression

Recommended Citations

Citations

  • Ickes, J. R. (2015). The Effects of Acute and Chronic Methamphetamine Exposure on Cardiovascular Development, Developmental Rate, and Aggression in Danio rerio [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1438456614

    APA Style (7th edition)

  • Ickes, Jessica. The Effects of Acute and Chronic Methamphetamine Exposure on Cardiovascular Development, Developmental Rate, and Aggression in Danio rerio. 2015. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1438456614.

    MLA Style (8th edition)

  • Ickes, Jessica. "The Effects of Acute and Chronic Methamphetamine Exposure on Cardiovascular Development, Developmental Rate, and Aggression in Danio rerio." Master's thesis, University of Akron, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=akron1438456614

    Chicago Manual of Style (17th edition)

akron1438456614
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This open access ETD is published by University of Akron and OhioLINK.