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N-HETEROCYCLIC CARBENE SILVER(I) COMPLEXES FROM XANTHINES AND THEIR ANTIMICROBIAL APPLICATIONS

Kascatan Nebioglu, Aysegul
http://rave.ohiolink.edu/etdc/view?acc_num=akron1176579309

Abstract Details

2007, Doctor of Philosophy, University of Akron, Chemistry.
This dissertation discusses a newly growing area of the synthesis from xanthine ligands of new silver(I) N- heterocyclic carbene (NHC) complexes and their potential antimicrobial use in cystic fibrosis lung infections. In chapter I, the ligand properties of NHCs and the synthetic methods for the formation of silver(I) NHC complexes are outlined. An overview of silver antimicrobials and previously synthesized silver(I) NHC complexes from pyridine linked and tripodal imidazolium salts for the topical applications is discussed. Furthermore, a brief summary of cystic fibrosis is given. Chapter II presents the introductory studies to explore the NHC silver(I) chemistry of caffeine. Formation and characterization of mono and dinuclear bis(NHC) silver(I) complexes from different methylated caffeine salts are given. Chapter III focuses on the formation of an NHC-silver(I) acetate complex from the iodide salt of methylated caffeine. This complex demonstrates a promising antimicrobial activity against numerous resistant respiratory pathogens including members of the Burkholderia cepacia complex which causes a high rate of mortality in patients with cystic fibrosis. Synthesis of NHC silver(I) complexes from theophylline derivatives is given in chapter IV. The antimicrobial activity of these complexes against the same pathogens used in chapter III is presented. In chapter V, the use of a bis(NHC) silver(I) complex from methylated caffeine as a carbene transfer agent is demonstrated and formation of a Rh(I) NHC complex is outlined. Furthermore, the synthesis and characterization of Pt(II) and Pd(II) NHC complexes of methylated caffeine are presented.
Wiley Youngs (Advisor)
NHC complexes; cystic fibrosis; caffeine; antimicrobial activity; silver

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Citations

  • Kascatan Nebioglu, A. (2007). N-HETEROCYCLIC CARBENE SILVER(I) COMPLEXES FROM XANTHINES AND THEIR ANTIMICROBIAL APPLICATIONS [Doctoral dissertation, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1176579309

    APA Style (7th edition)

  • Kascatan Nebioglu, Aysegul. N-HETEROCYCLIC CARBENE SILVER(I) COMPLEXES FROM XANTHINES AND THEIR ANTIMICROBIAL APPLICATIONS. 2007. University of Akron, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1176579309.

    MLA Style (8th edition)

  • Kascatan Nebioglu, Aysegul. "N-HETEROCYCLIC CARBENE SILVER(I) COMPLEXES FROM XANTHINES AND THEIR ANTIMICROBIAL APPLICATIONS." Doctoral dissertation, University of Akron, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=akron1176579309

    Chicago Manual of Style (17th edition)

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© 2007, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.