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LONG-TERM CRANIAL RECONSTRUCTIONS IN FULL THICKNESS DEFECTS USING CARBONATED CALCIUM PHOSPHATE CEMENT WITH TITANIUM MESH SCAFFOLD IN A SHEEP MODEL: BIOMECHANICAL ANALYSIS

Parikh, Anand
http://rave.ohiolink.edu/etdc/view?acc_num=akron1164993505

Abstract Details

2006, Master of Science in Engineering, University of Akron, Biomedical Engineering.
Autogenous bone graft (ABG) is considered the evaluation standard for cranial defect reconstruction material. A variety of bone substitutes have been used as alternative materials for this procedure, each having its own advantages and disadvantages. Carbonated calcium phosphate (CCPP), a biomaterial form of hydroxyapatite (HA), has been increasingly used for cranial reconstructions. For defects of certain size and shape, CCPP is used with a titanium mesh for structural stability. At the present time there have been no published studies in the literature comparing the biomechanical and histological properties of these cranial bone reconstruction structures over time. In this study two different reconstruction structures were compared to autogenous bone grafts with respect to time. Reconstruction structure A (RCA) used a slow setting CCPP, whereas reconstruction structure B (RCB) used a fast setting CCPP. Unilateral or bilateral cranial defect reconstructions were conducted on sheep with full thickness defect sizes of 1.5 × 3.0 cm. A total of 24 sheep were divided into eight groups with post surgical periods of 0, 6 and 12 months. The skulls’ biomechanical properties were evaluated using a free weight drop test protocol. In addition, intact parietal bone was also evaluated at 12 months as a control. Peak acceleration, peak force transmission and time to peak acceleration parameters obtained from the drop weight test were used for analysis. Immediately post-surgery there were no significant differences in any biomechanical characteristics of the experimental groups. At 12 months, the autogenous bone graft (ABG) reconstructions had a significantly superior impact characteristic compared to reconstructions of slow setting CCPP with titanium mesh scaffold and reconstructions of fast setting CCPP with titanium mesh scaffold (p<0.05). At 12 months ABG was not significantly different from the intact bone (p>0.05).
Glen Njus (Advisor)
96 p.
Biomechanical testing; Drop weight test; Hydroxyapatite cement; Cranial reconstruction; Calcium phosphate cement

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Citations

  • Parikh, A. (2006). LONG-TERM CRANIAL RECONSTRUCTIONS IN FULL THICKNESS DEFECTS USING CARBONATED CALCIUM PHOSPHATE CEMENT WITH TITANIUM MESH SCAFFOLD IN A SHEEP MODEL: BIOMECHANICAL ANALYSIS [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1164993505

    APA Style (7th edition)

  • Parikh, Anand. LONG-TERM CRANIAL RECONSTRUCTIONS IN FULL THICKNESS DEFECTS USING CARBONATED CALCIUM PHOSPHATE CEMENT WITH TITANIUM MESH SCAFFOLD IN A SHEEP MODEL: BIOMECHANICAL ANALYSIS. 2006. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1164993505.

    MLA Style (8th edition)

  • Parikh, Anand. "LONG-TERM CRANIAL RECONSTRUCTIONS IN FULL THICKNESS DEFECTS USING CARBONATED CALCIUM PHOSPHATE CEMENT WITH TITANIUM MESH SCAFFOLD IN A SHEEP MODEL: BIOMECHANICAL ANALYSIS." Master's thesis, University of Akron, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=akron1164993505

    Chicago Manual of Style (17th edition)

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This open access ETD is published by University of Akron and OhioLINK.