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Degree

Master of Science in Chemistry, Youngstown State University, Department of Chemistry, 2007.

Abstract

The following details attempts at a stereoselective synthesis of deoxygenated D-mannose uronic acid derivatives from D-glucurono-6,3-lactone. These derivatives will be tested as potential inhibitors of enzymes used by Staphylococcus aureus to form its polysaccharide microcapsule, which functions as a protective barrier against destruction by the host. Two serotypes (types 5 and 8) comprise the majority of S. aureus bacteria and also the most virulent strains of this bacterium.

The goal of this research project is to synthesize glycomimetics of D-ManNAcA that may act as potential inhibitors of the enzymes such as UDP-GlcNAc 2-epimerase.

Since infections caused by S. aureus are an increasing threat in hospitals and the general community, it is of considerable interest within the biological community to find new treatments to combat these drug-resistant bacteria.

Subject Headings

Chemistry

Keywords

carbohydrate; S. aureus; glycobiology; capsular polysaccharide

Committee / Advisors

Peter Norris, PhD (Advisor)
John Jackson, PhD (Committee Member)
Tim Wagner, PhD (Committee Member)

Pages

xiii, 213p.

Document number: ysu1217344144
Permalink: http://rave.ohiolink.edu/etdc/view?acc_num=ysu1217344144

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