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Degree

Master of Science in Biology, Youngstown State University, Department of Biological Sciences, 2000.

Abstract

NK cells, a component of our innate immune system, are responsible for the elimination of virus-infected and tumor cells which bypass detection by T-cells. In these studies, we attempted to create a NK cell hybridoma clone, which would provide a testable pool of NK cells. Mouse splenocytes were fused with P3X mouse non-secreting myeloma cells in the presence of polyethylene glycol (PEG). Following HAT selection, the cells were tested for the presence of the mouse NK cell surface antigen DX5.

Subject Headings

Biology, Cell

Keywords

clone cells

Advisor

Diane L. Fagan

Pages

viii, 98p.

Document number: ysu1004458025
Permalink: http://rave.ohiolink.edu/etdc/view?acc_num=ysu1004458025

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