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Degree

Master of Science (MS), Wright State University, Chemistry, 2011.

Abstract

This work encompassed synthesis and characterization of biocompatible hyperbranched polyester drug delivery systems prepared with fumaric acid, glycerol and polyethylene glycol. The polymers were manufactured in the melt utilizing A2 + CB2 polymerization. The ratio of A2:CB2 was modified and excess B was added to end-cap the polymers to avoid cross-linking. Fumaric acid was selected as the A2 monomer because the double bond provided a site for polymer backbone modification or covalent attachment of active pharmaceutical ingredients. Acetaminophen and Ondansetron Hydrochloride were added to evaluate feasibility of using the polyesters as drug delivery systems. The weight average molecular weight of the A2 + CB2 polymer systems with the end-capping agent ranged from 5100 to 8500 Da with PDI values between 1.3 and 1.7. The polymers containing Acetaminophen appeared to degrade while the polymers with Ondansetron were determined to be immediate-release dosage forms.

Subject Headings

Chemistry; Organic Chemistry; Polymer Chemistry

Keywords

A2 + CB2 polymerization; end-capped polymers

Committee / Advisors

Eric Fossum, PhD (Committee Chair)
William Feld, PhD (Committee Member)
Kenneth Turnbull, PhD (Committee Member)

Pages

59p.

Document number: wright1316178520
Permalink: http://rave.ohiolink.edu/etdc/view?acc_num=wright1316178520

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