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Degree

Master of Science (MS), Wright State University, Pharmacology and Toxicology, 2006.

Abstract

The present study was conducted to determine the half-life, assess the toxicity, and passive protection efficacy of purified immunoglobulin G (IgG) from Anthrax Vaccine Adsorbed (AVA) vaccinated human donors. Half-life determinations were calculated from the reportable values obtained using the anti-PA ELISA assay and the Centers for Disease Control’s (CDC) “ELISA for Windows” software. For toxicity evaluations animals were observed clinical for one hour post administration and for 14-days post-treatment. The protection efficacy was determined based upon the mortality results from a lethal Bacillus anthracis aerosol challenge. While no protection was achieved in this delayed exposure scenario, the study yielded valuable kinetics data for use in future research.

Subject Headings

Biology, General

Keywords

ELISA; AIG; anti-PA; Naïve; IgG; LOQ; Diluent

Advisor

Robert P. Casillas

Pages

75p.

Document number: wright1166813637
Permalink: http://rave.ohiolink.edu/etdc/view?acc_num=wright1166813637

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