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Degree

Master of Science, Ohio State University, Veterinary Clinical Sciences, 2009.

Abstract

Biomaterials can increase bone-implant interface stability. In this study four cortical screws were inserted in both 3rd metacarpal and 3rd metatarsal bones of 6 horses with calcium(Ca)-cement, magnesium(Mg)-cement, polymethylmethacrylate (PMMA) or left untreated. Specimens were harvested for analysis 5 or 182 days postoperatively. Radiography, biomechanical testing, histomorphometry and micro computed tomography were performed to characterize the bone-implant interfaces. Mg-cement significantly increased the extraction torque compared to control and Ca-cement and interface toughness compared to control, Ca-cement and PMMA. This improved interface strength was also observed during the 6 month follow-up period as one of the untreated screws and one Ca-treated screw backed out. Histologically there was 44% reduction in the quantity of Ca-cement and 69% reduction in the quantity of Mg-cement at 182 days. These results suggest that Mg-cement is a biodegradable bone cement, which can improve the biomechanical strength of the bone-implant interface.

Subject Headings

Surgery; Veterinary services

Keywords

bone cement; magnesiumphosphate cement; calciumphosphate cement; PMMA; extraction torque; bone-screw interface; horse

Committee / Advisors

Alicia Bertone, PhD (Advisor)
Steven Weisbrode, PhD (Committee Member)
Yvonne Elce, DVM (Committee Member)

Pages

51p.

Document number: osu1243434636
Permalink: http://rave.ohiolink.edu/etdc/view?acc_num=osu1243434636

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