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Degree

Master of Science, Ohio State University, Biomedical Engineering, 2008.

Abstract

A finite element method is combined with control theory and used to model bone’s shape and density adaptations. The model is implemented using Simulink (The MathWorks Inc., Natick, MA) along with functions from MATLAB (The MathWorks Inc., Natick, MA) and COMSOL (COMSOL Inc., Burlington, MA). Regulators of shape and density adaptations are user-definable as a function of time or as a function of a mechanical signal such as strain. The described technique is used to simulate the adaptations in a tissue engineered bone graft, or bone flap. First, the functionality of each of the remodeling rules is demonstrated. Then, shape and density remodeling is combined to replicate the bone flap’s adaptations and compared to experimental data. Finally, the model is used to theorize how the bone flap may behave when reimplanted during a maxilla reconstruction.

Subject Headings

Biomedical research; Engineering; Mechanical engineering

Keywords

finite element; bone flap; shape adaptation; density adaptation

Committee / Advisors

Richard T. Hart, PhD (Advisor)
Alan S. Litsky, ScD, MD (Committee Member)

Pages

175p.

Document number: osu1229980146
Permalink: http://rave.ohiolink.edu/etdc/view?acc_num=osu1229980146

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