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Degree

Master of Science in Pharmaceutical Science (MSP), University of Toledo Health Science Campus, College of Pharmacy, 2012.

Abstract

The objective of this study is to prepare and evaluate the effect of Poloxamer 407 on the sedimentation behavior of never dried magnesium hydroxide suspensions. Never dried magnesium hydroxide suspensions have been prepared stoichiometrically by adding sodium hydroxide to magnesium sulfate. The effect of rate of addition of sodium hydroxide on particle size has also been studied. The hindered settling behavior of these suspensions was observed by adding various concentrations of Poloxamer, such as 0.025%, 0.05% and 0.075% (w/v). Particle size was determined using modified Stoke’s equations along with laser diffraction and SEM for surface morphology. It was found that the particle size increased upon flocculation and with an increase in Poloxamer concentration. Laser diffraction was not consistent with hindered settling results and will be explained. Permeability studies indicate a decreased permeability with increased flocculation because of reduced pore sizes. Zeta potential studies demonstrated the mechanism of action of Poloxamer in flocculating the system. Thermal analysis studies have been performed to determine the bound and unbound water content of the suspensions. It has been observed that increasing flocculation brought about a decrease in bound water content. PXRD studies established the degradation of magnesium hydroxide to magnesium oxide at around 420oC.

Subject Headings

Pharmaceuticals

Keywords

Sedimentation; Poloxamer; never dried suspensions; hindered settling

Committee / Advisors

Kenneth Alexander, PhD (Committee Chair)
Sai Hanuman Sagar Boddu, PhD (Committee Member)
Ming-Cheh Liu, PhD (Committee Member)

Pages

149p.

Document number: mco1352945106
Permalink: http://rave.ohiolink.edu/etdc/view?acc_num=mco1352945106

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