Display Full Text | Download Full Text
1.79 MB PDF file

Degree

Master of Science in Biomedical Sciences (MSBS), University of Toledo Health Science Campus, Graduate School, 2004.

Abstract

This thesis examines new vessel formation in Choroidal Neovascularization (CNV) and the treatment of feeder vessels in CNV. Indocyanine Green (ICG) enhanced laser photocoagulation of CNV feeder vessels was studied and the histological findings reported. Data revealed that intravascular thrombus resulting in vessel closure was achieved and reproducible. However, vessel recanilization occurred with concomitant inflammatory cell infiltrate and the closure was temporary. The understanding of vessel formation in CNV is under active investigation. While current paradigms focus on angiogenesis it is hypothesized that vasculogenesis also plays a role in CNV. Data from this study reveals that Endothelial Progenitor Cells (EPCs) contribute to the formation of CNV and local expression of Vascular Endothelial Growth Factor (VEGF) is important in the recruitment of EPCs.

Keywords

choroidal neovascularization; indocyanine green; rodent; laser photocoagulation; vascular endotheial growth factor; bone marrow

Advisor

Mark Hankin, Ph.D

Pages

100p.

Document number: mco1095878383
Permalink: http://rave.ohiolink.edu/etdc/view?acc_num=mco1095878383

This ETD has been downloaded 702 times (through March 2013)